Hypoglycemic Active Components and Mechanism of Bitter Gourd

Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd

This study aimed to examine the role of GLP-1 in the hypoglycemic activity of wild bitter gourd (Momordica charantia L., BG). In vitro, the GLP-1 secretion in STC-1, a murine enteroendocrine cell line, was dose dependently stimulated by water extract (WE), its fractions (WEL, >3 kD and WES, <3 kD), and a bitter compounds-rich fraction of BG. These stimulations were partially inhibited by proben...

Genetic Divergence in Bitter Gourd

The genetic divergence among 36 genotypes of bitter gourd (Momordica charantia L.) was determined through PCA, PCO, CVA, Cluster analysis (CLSA) and Mohalanobis’s D analysis. Through multivariate analysis based on 22 characters 36 genotypes were grouped into six distant clusters. Cluster VI includes maximum genotypes (12) followed by cluster I (6) and cluster II (6). Cluster V, cluster III and ...

Evaluation of the efficacy of bitter gourd (momordica charantia) as an oral hypoglycemic agent--a randomized controlled clinical trial.

Patients were randomized to receive either bitter gourd tablets (26 subjects) or placebo (24 subjects). The bitter gourd tablets were made from shade dr ied powdered fresh whole fruit. The average sized fruit weights around 5 gm when dried. Each tablet contained 1 gm of dried fruit and each patient received 2 tablets thrice daily, after meals. Riboflavin was given as placebo, as placebo identic...

Anticlastogenic and anticarcinogenic potential of Thai bitter gourd fruits.

Thai bitter gourd fruits (Momordica charantia Linn., TBG) has been previously demonstrated to possess phase II detoxificating enzymes inducing properties, as well as the ability to reduce phase I carcinogen activating enzyme activity in rat liver. In addition, it was partially inhibited 7,12-dimethylbenz(a)anthracene (DMBA)- induced mammary gland carcinogenesis in female Sprague-Dawley rats. In...

The Distribution and Application of Bitter Gourd in China